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Article

Mutations and chromosomal rearrangements of JAK2: not only a myeloid issue.

Expert review of hematology - 1 Aug 2013

Salmoiraghi Silvia, Montalvo Marie Lorena Guinea, D'Agostini Elena, Amicarelli Giulia, Minnucci Giulia, Spinelli Orietta, Rambaldi Alessandro

Abstract excerpt

Until today, JAK2 alterations have been mainly associated with myeloid malignancies among which they play a key pathogenic role in chronic myeloproliferative neoplasms. More recently, aberrations involving the JAK2 gene have also been reported in lymphoid diseases, including acute leukemia and lymphomas. In addition, the constitutively activating JAK2V617F mutation has been identified in some patients affected by...

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Topics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23991929
DOI: 10.1586/17474086.2013.826910

Genes

JAK2
JAK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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