Article
Differential transcriptional expresión of the polymorphic myxovirus resistance protein A in response to interferon-alpha treatment.
Pharmacogenetics - 1 Mar 2004
Fernández-Arcás Nieves, Blanco Asunción, Gaitán M Jesús, Nyqvist Maria, Alonso Antonio, Reyes-Engel Armando
Abstract excerpt
Levels of myxovirus resistance protein A (MxA) mRNA were studied for a single nucleotide polymorphism in the promoter region at nucleotide position -88 of the gene to identify individual-specific responses to interferon (IFN)-alpha2 that might predict responsiveness to IFN-alpha therapy. We quantified MxA expression by reverse transcription and real-time polymerase chain reaction in peripheral blood mononuclear...
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