Article
Putative association of polymorphism in the mannose 6-phosphate receptor gene with major depression and Alzheimer's disease.
Psychiatric genetics - 1 Jun 2004
Kölsch Heike, Ptok Ursula, Majores Michael, Schmitz Sandra, Rao Marie Luise, Maier Wolfgang, Heun Reinhard
Abstract excerpt
The endosomal lysosomal system might play a role in Alzheimer's disease, but its impact in major depression is unknown. The expression of the cation-dependent mannose 6-phosphate receptor (CD-MPR) is increased in Alzheimer's disease and the CD-MPR gene is located next to a region on chromosome 12 possibly linked to Alzheimer's disease. We investigated a C/T polymorphism in the CD-MPR gene in 188 Alzheimer's...
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