Article
Altering a gene involved in nuclear distribution increases the repeat-induced point mutation process in the fungus Podospora anserina.
Genetics - 1 May 2004
Bouhouche Khaled, Zickler Denise, Debuchy Robert, Arnaise Sylvie
Abstract excerpt
Repeat-induced point mutation (RIP) is a homology-dependent gene-silencing mechanism that introduces C:G-to-T:A transitions in duplicated DNA segments. Cis-duplicated sequences can also be affected by another mechanism called premeiotic recombination (PR). Both are active over the sexual cycle of some filamentous fungi, e.g., Neurospora crassa and Podospora anserina. During the sexual cycle, several developmental...
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