Article
Mutations in mating-type genes greatly decrease repeat-induced point mutation process in the fungus Podospora anserina.
Fungal genetics and biology : FG & B - 1 Mar 2008
Arnaise Sylvie, Zickler Denise, Bourdais Anne, Dequard-Chablat Michelle, Debuchy Robert
Abstract excerpt
RIP (Repeat-Induced point Mutation) and PR (Premeiotic Recombination) are two developmentally regulated processes in filamentous ascomycetes. RIP detects and mutates duplicated DNA sequences, while PR results in deletion of the interstitial sequence between cis-duplicated DNA sequences. These two silencing processes take place between fertilization and premeiotic replication, a period during which the mating-type...
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