Article
Homozygosity at the MTL locus in clinical strains of Candida albicans: karyotypic rearrangements and tetraploid formation.
Molecular microbiology - 1 Jun 2004
Legrand Melanie, Lephart Paul, Forche Anja, Mueller Frank-Michael C, Walsh T, Magee P T, Magee Beatrice B
Abstract excerpt
One hundred and twenty Candida albicans clinical isolates from the late 1980s and early 1990s were examined for homozygosity at the MTL locus. Of these, 108 were heterozygous (MTLa/MTLalpha), whereas seven were MTLa and five were MTLalpha. Five of the homozygous isolates were able to switch to the opaque cell morphology, while opaque cells were not detectable among the remaining seven. Nevertheless, all but one...
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