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Evolution of Fluconazole-Resistant Candida albicans Strains by Drug-Induced Mating Competence and Parasexual Recombination

4 Feb 2019

Abstract excerpt

Sexual reproduction is an important mechanism in the evolution of species, since it allows the combination of advantageous traits of individual members in a population. The pathogenic yeast Candida albicans is a diploid organism that normally propagates in a clonal fashion, because heterozygosity at the mating type locus ( MTL ) inhibits mating between cells. Here we show that C. albicans cells that have acquired...

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PMID: 30723130
DOI: 10.1128/mbio.02740-18

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