Article
Rapid and sensitive p53 alteration analysis in biopsies from lung cancer patients using a functional assay and a universal oligonucleotide array: a prospective study.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 May 2004
Fouquet Coralie, Antoine Martine, Tisserand Pascaline, Favis Reyna, Wislez Marie, Commo Fréderic, Rabbe Nathalie, Carette Marie France, Milleron Bernard, Barany Francis, Cadranel Jacques, Zalcman Gérard, Soussi Thierry
Abstract excerpt
PURPOSE: Molecular profiling of alterations associated with lung cancer holds the promise to define clinical parameters such as response to treatment or survival. Because <5% of small cell lung cancers and <30% of non-small cell lung cancers are surgically resectable, molecular analysis will perforce rely on routinely available clinical samples such as biopsies. Identifying tumor mutations in such samples will...
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