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Article

Diagnostic Mutation Profiling and Validation of Non-Small-Cell Lung Cancer Small Biopsy Samples using a High Throughput Platform.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 May 2015

Quinn Anne Marie, Hickson Nicholas, Adaway Megan, Priest Lynsey, Jaeger Erich, Udar Nitin, Keeling Catherine, Kamieniorz Martyna, Dive Caroline, Wallace Andrew, Byers Richard J, Newman William G, Nonaka Daisuke, Blackhall Fiona H

Abstract excerpt

BACKGROUND: A single platform designed for the synchronous screening of multiple mutations can potentially enable molecular profiling in samples of limited tumor tissue. This approach is ideal for the assessment of advanced non-small-cell lung cancer (NSCLC) diagnostic specimens, which often comprise small biopsies. Therefore, we aimed in this study to validate the mass spectrometry-based Sequenom LungCarta panel...

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PMID: 25634010
DOI: 10.1097/JTO.0000000000000473

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EGFR
EPHA3
EPHA5
KRAS
MET
STK11

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