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Telomere length and telomerase subunits as diagnostic and prognostic biomarkers in Barrett carcinoma

17 Mar 2008

Abstract excerpt

BACKGROUND: Maintenance of telomeres has been identified as an essential regulator of proliferative capacity and genomic integrity in malignant tumors. The authors evaluated telomere length and telomerase subunits, hTR and hTERT, as prognostic markers in patients with Barrett carcinoma. METHODS: Telomere length was measured by Southern blot analysis and hTR expression and hTERT expression by real-time polymerase...

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PMID: 18348304
DOI: 10.1002/cncr.23419

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