Article
Signal transduction therapy in haematological malignancies: identification and targeting of tyrosine kinases.
Clinical science (London, England : 1979) - 1 Oct 2006
Chase Andrew, Cross Nicholas C P
Abstract excerpt
Tyrosine kinases play key roles in cell proliferation, survival and differentiation. Their aberrant activation, caused either by the formation of fusion genes by chromosome translocation or by intragenic changes, such as point mutations or internal duplications, is of major importance in the development of many haematological malignancies. An understanding of the mechanisms by which BCR-ABL contributes to the...
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