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Article

MuSK is required for anchoring acetylcholinesterase at the neuromuscular junction.

The Journal of cell biology - 24 May 2004

Cartaud Annie, Strochlic Laure, Guerra Manuel, Blanchard Benoît, Lambergeon Monique, Krejci Eric, Cartaud Jean, Legay Claire

Abstract excerpt

At the neuromuscular junction, acetylcholinesterase (AChE) is mainly present as asymmetric forms in which tetramers of catalytic subunits are associated to a specific collagen, collagen Q (ColQ). The accumulation of the enzyme in the synaptic basal lamina strictly relies on ColQ. This has been shown to be mediated by interaction between ColQ and perlecan, which itself binds dystroglycan. Here, using transfected...

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Identifiers

PMID: 15159418
DOI: 10.1083/jcb.200307164
PMCID: PMC2172359

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

MuSK is required for anchoring acetylcholinesterase at the neuromuscular junction.PMID 15159418Read ↗

Developmental consequences of the ColQ/MuSK interactions.Semantic proximity Read ↗

COOH-terminal collagen Q (COLQ) mutants causing human deficiency of endplate acetylcholinesterase impair the interaction of ColQ with proteins of the basal lamina.Semantic proximity Read ↗

Mutations in the C-Terminal Domain of ColQ in Endplate Acetylcholinesterase Deficiency Compromise ColQ-MuSK InteractionSemantic proximity Read ↗

Structural and functional organization of synaptic acetylcholinesterase.Semantic proximity Read ↗

The synaptic muscle‐specific kinase (MuSK) complex: New partners, new functionsSemantic proximity Read ↗

C-terminal and heparin-binding domains of collagenic tail subunit are both essential for anchoring acetylcholinesterase at the synapse.Semantic proximity Read ↗

Cholinesterases regulation in the absence of ColQ.Semantic proximity Read ↗

[Molecular bases and therapeutic strategies in defective neuromuscular transmissions: lessons learned from a prototypical synapse].Semantic proximity Read ↗

Distinct domains of MuSK mediate its abilities to induce and to associate with postsynaptic specializations.Semantic proximity Read ↗

Trimerization domain of the collagen tail of acetylcholinesterase.Semantic proximity Read ↗

SH3BP2 regulates the organization of the neuromuscular synapses through protein-driven phase separationSemantic proximity Read ↗

A synaptic laminin-calcium channel interaction organizes active zones in motor nerve terminals.Semantic proximity Read ↗

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