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Article

Cholinesterases regulation in the absence of ColQ.

Chemico-biological interactions - 6 Sept 2010

Sigoillot Séverine M, Bourgeois Francine, Legay Claire

Abstract excerpt

Normal physiological activity of the neuromuscular junction (NMJ) requires that key molecules are clustered at the synapse. One of these molecules is acetylcholinesterase (AChE) that regulates acetylcholine levels. This enzyme exists under different isoforms but the predominant form at the NMJ is...

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Identifiers

PMID: 20153305
DOI: 10.1016/j.cbi.2010.02.007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20153305-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Cholinesterases regulation in the absence of ColQ.PMID 20153305Read ↗

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Transcriptional control of different acetylcholinesterase subunits in formation and maintenance of vertebrate neuromuscular junctions.Semantic proximity Read ↗

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Two novel mutations in the COLQ gene cause endplate acetylcholinesterase deficiency.Semantic proximity Read ↗

Clinical and molecular genetic findings in COLQ-mutant congenital myasthenic syndromes.Semantic proximity Read ↗

MuSK is required for anchoring acetylcholinesterase at the neuromuscular junction.Semantic proximity Read ↗

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Synaptic congenital myasthenic syndrome in three patients due to a novel missense mutation (T441A) of the COLQ gene.Semantic proximity Read ↗

C-terminal and heparin-binding domains of collagenic tail subunit are both essential for anchoring acetylcholinesterase at the synapse.Semantic proximity Read ↗

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