Structural and functional organization of synaptic acetylcholinesterase.

doi:10.1016/j.brainresrev.2004.07.019

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Article

Structural and functional organization of synaptic acetylcholinesterase.

Brain research. Brain research reviews - 1 Dec 2004

Aldunate Rebeca, Casar Juan Carlos, Brandan Enrique, Inestrosa Nibaldo C

Abstract excerpt

The expression of the synaptic asymmetric form of the enzyme acetylcholinesterase (AChE) depends of two different genes: the gene that encodes for the catalytic subunit and the gene that encodes for the collagenic tail, ColQ. Asymmetric AChE is specifically localized to the basal lamina at the neuromuscular junction (NMJ). This highly organized distribution pattern suggests the existence of one or more specific...

Topics

Acetylcholine
Acetylcholinesterase
Animals
Binding Sites
Heparan Sulfate Proteoglycans
Humans
Mice
Mutation
Neuromuscular Junction
Protein Structure, Tertiary
Synaptic Membranes
Synaptic Transmission

Source

Open in PubMed

Identifiers

PMID: 15572165
DOI: 10.1016/j.brainresrev.2004.07.019

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