Article
A heptosyltransferase mutant of Pasteurella multocida produces a truncated lipopolysaccharide structure and is attenuated in virulence.
Infection and immunity - 1 Jun 2004
Harper Marina, Cox Andrew D, St Michael Frank, Wilkie Ian W, Boyce John D, Adler Ben
Abstract excerpt
Pasteurella multocida is the causative agent of fowl cholera in birds. In a previous study using signature-tagged mutagenesis, we identified a mutant, AL251, which was attenuated for virulence in mice and in the natural chicken host. Sequence analysis indicated that AL251 had an insertional inactivation of the gene waaQ(PM), encoding a putative heptosyl transferase, required for the addition of heptose to...
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