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Clearance of<i>Citrobacter rodentium</i>Requires B Cells but Not Secretory Immunoglobulin A (IgA) or IgM Antibodies

20 May 2004

Abstract excerpt

Citrobacter rodentium, a murine model pathogen for human enteropathogenic Escherichia coli, predominantly colonizes the lumen and mucosal surface of the colon and cecum and causes crypt hyperplasia and mucosal inflammation. Mice infected with C. rodentium develop a secretory immunoglobulin A (IgA) response, but the role of B cells or secretory antibodies in host defense is unknown. To address this question, we...

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PMID: 15155635
DOI: 10.1128/iai.72.6.3315-3324.2004

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