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Article

tcaA inactivation increases glycopeptide resistance in Staphylococcus aureus.

Antimicrobial agents and chemotherapy - 1 Jun 2004

Maki Hideki, McCallum Nadine, Bischoff Markus, Wada Akihito, Berger-Bächi Brigitte

Abstract excerpt

The experimental deletion of the tcaRAB region has been shown to increase teicoplanin resistance in Staphylococcus aureus. By sequential genetic complementation of a tcaRAB mutant, we identified tcaA as the key gene within tcaRAB that is responsible for changes in glycopeptide resistance levels. Northern blot analysis of the tcaRAB region showed that the tcaA gene is expressed only weakly over the growth cycle...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15155184
DOI: 10.1128/AAC.48.6.1953-1959.2004
PMCID: PMC415614

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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