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Article

Isolation and functional expression of human COQ3, a gene encoding a methyltransferase required for ubiquinone biosynthesis.

The Journal of biological chemistry - 28 Apr 2000

Jonassen T, Clarke C F

Abstract excerpt

The COQ3 gene in Saccharomyces cerevisiae encodes an O-methyltransferase required for two steps in the biosynthetic pathway of ubiquinone (coenzyme Q, or Q). This enzyme methylates an early Q intermediate, 3,4-dihydroxy-5-polyprenylbenzoic acid, as well as the final intermediate in the pathway, converting demethyl-Q to Q. This enzyme is also capable of methylating the distinct prokaryotic early intermediate...

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Source

Identifiers

PMID: 10777520
DOI: 10.1074/jbc.275.17.12381

Genes

COQ3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Isolation and functional expression of human COQ3, a gene encoding a methyltransferase required for ubiquinone biosynthesis.PMID 10777520Read ↗

Ubiquinone biosynthesis in Saccharomyces cerevisiae. Isolation and sequence of COQ3, the 3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase gene.Semantic proximity Read ↗

Functional characterization of human COQ4, a gene required for Coenzyme Q10 biosynthesis.Semantic proximity Read ↗

Complementation of coq3 mutant yeast by mitochondrial targeting of the Escherichia coli UbiG polypeptide: evidence that UbiG catalyzes both O-methylation steps in ubiquinone biosynthesis.Semantic proximity Read ↗

Isolation and functional expression of human COQ2, a gene encoding a polyprenyl transferase involved in the synthesis of CoQ.Semantic proximity Read ↗

Coenzyme Q10 deficiencies: pathways in yeast and humans.Semantic proximity Read ↗

COQ4 mutations cause a broad spectrum of mitochondrial disorders associated with CoQ10 deficiency.Semantic proximity Read ↗

The molecular genetics of coenzyme Q biosynthesis in health and disease.Semantic proximity Read ↗

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Coq10, a mitochondrial coenzyme Q binding protein, is required for proper respiration in Schizosaccharomyces pombe.Semantic proximity Read ↗

The COQ2 genotype predicts the severity of coenzyme Q10 deficiency.Semantic proximity Read ↗

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The Saccharomyces cerevisiae COQ6 gene encodes a mitochondrial flavin-dependent monooxygenase required for coenzyme Q biosynthesis.Semantic proximity Read ↗

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