Marked Up-Regulation of ACE2 in Hearts of Patients With Obstructive Hypertrophic Cardiomyopathy: Implications for SARS-CoV-2-Mediated COVID-19.

doi:10.1016/j.mayocp.2020.04.028

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Article

Marked Up-Regulation of ACE2 in Hearts of Patients With Obstructive Hypertrophic Cardiomyopathy: Implications for SARS-CoV-2-Mediated COVID-19.

Mayo Clinic proceedings - 1 Jul 2020

Bos J Martijn, Hebl Virginia B, Oberg Ann L, Sun Zhifu, Herman Daniel S, Teekakirikul Polakit, Seidman Jonathan G, Seidman Christine E, Dos Remedios Cristobal G, Maleszewski Joseph J, Schaff Hartzell V, Dearani Joseph A, Noseworthy Peter A, Friedman Paul A, Ommen Steve R, Brozovich Frank V, Ackerman Michael J

Abstract excerpt

OBJECTIVE: To explore the transcriptomic differences between patients with hypertrophic cardiomyopathy (HCM) and controls. PATIENTS AND METHODS: RNA was extracted from cardiac tissue flash frozen at therapeutic surgical septal myectomy for 106 patients with HCM and 39 healthy donor hearts. Expression profiling of 37,846 genes was performed using the Illumina Human HT-12v3 Expression BeadChip. All patients with...

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PMID: 32448590
DOI: 10.1016/j.mayocp.2020.04.028
PMCID: PMC7186205

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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