Article
Investigation of the basis of virulence in serotype A strains of Cryptococcus neoformans from apparently immunocompetent individuals.
Current genetics - 1 Aug 2004
D'Souza Cletus A, Hagen Ferry, Boekhout Teun, Cox Gary M, Heitman Joseph
Abstract excerpt
Cryptococcus neoformans serotype A strains commonly infect immunocompromised patients to cause fungal meningitis. To understand the basis of serotype A cryptococcal infections in apparently immunocompetent patients, we tested two hypotheses: the strains were naturally occurring hypervirulent pkr1...
Topics
- Blotting, Southern
- Cluster Analysis
- Cryptococcus neoformans
- Cyclic AMP-Dependent Protein Kinases
- DNA Primers
- Genetic Complementation Test
- Humans
- Hybridization, Genetic
- Immunocompetence
- Meningitis, Fungal
- Nucleic Acid Amplification Techniques
- Phenotype
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length