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Article

Molecular interactions of fission yeast Skp1 and its role in the DNA damage checkpoint.

Genes to cells : devoted to molecular & cellular mechanisms - 1 May 2004

Lehmann Anna, Katayama Satoshi, Harrison Clare, Dhut Susheela, Kitamura Kenji, McDonald Neil, Toda Takashi

Abstract excerpt

Skp1 is a central component of the E3 ubiquitin ligase SCF (Skp1-Cullin-1-F-box). It forms an adapter bridge between Cullin-1 and the substrate-determining component, the F-box protein. In order to establish the role of Skp1, a temperature sensitive (ts) screen was carried out using mutagenic PCR (polymerase chain reaction) and 9 independent ts mutants were isolated. Mapping the mutated residues on the 3-D...

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Identifiers

PMID: 15147268
DOI: 10.1111/j.1356-9597.2004.00730.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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