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Article

Mapping and analysis of HPV16 integration sites in a head and neck cancer cell line

16 Mar 2004

Abstract excerpt

Human papillomavirus (HPV) is a circular double-stranded DNA virus implicated in at least 90% of cervical and anogenital cancers and has been observed in approximately 20% of squamous cell carcinomas of the head and neck (SCCHN). Transcription of the viral oncogenes E6 and E7 is regulated by expression of the E2 protein. Disruption of the E2 gene sequence due to viral integration results in upregulation of E6 and...

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Identifiers

PMID: 15146560
DOI: 10.1002/ijc.20193

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