Article
Insidious cognitive decline in CADASIL.
Stroke - 1 Jul 2004
Amberla Kaarina, Wäljas Minna, Tuominen Susanna, Almkvist Ove, Pöyhönen Minna, Tuisku Seppo, Kalimo Hannu, Viitanen Matti
Abstract excerpt
BACKGROUND AND PURPOSE: Cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) causes repeated ischemic attacks leading to subcortical vascular dementia. The aim of this study was to characterize cognitive function in subjects with a C475T (R133C) mutation in the Notch3 gene, leading to CADASIL. METHODS: Prestroke (n=13) and poststroke (n=13) mutation carriers and...
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