Article
CADASIL: a critical look at a Notch disease.
Developmental neuroscience - 1 Jan 2006
Louvi Angeliki, Arboleda-Velasquez Joseph F, Artavanis-Tsakonas Spyros
Abstract excerpt
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a catastrophic late-onset syndrome which manifests itself mainly as a central nervous system degenerative disorder. CADASIL has been associated with mutations in the Notch 3 receptor which appear to cause, mainly, vascular abnormalities. Although more than a decade has passed since Notch 3 mutations were linked...
Topics
- Animals
- Blood Vessels
- CADASIL
- Disease Models, Animal
- Genetic Predisposition to Disease
- Humans
- Mutation
- Protein Structure, Tertiary
- Receptor, Notch3
- Receptors, Notch
- Signal Transduction