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Article

Lacunar infarcts are the main correlate with cognitive dysfunction in CADASIL.

Stroke - 1 Mar 2007

Liem Michael K, van der Grond Jeroen, Haan Joost, van den Boom Rivka, Ferrari Michel D, Knaap Yvette M, Breuning Martijn H, van Buchem Mark A, Middelkoop Huub A M, Lesnik Oberstein Saskia A J

Abstract excerpt

BACKGROUND AND PURPOSE: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy is caused by mutations in the NOTCH3 gene and is clinically characterized by recurrent stroke and cognitive decline. Previous studies have shown an association between white matter hyperintensities on brain MRI and cognitive dysfunction in cerebral autosomal dominant arteriopathy with subcortical...

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Source

Identifiers

PMID: 17272761
DOI: 10.1161/01.STR.0000257968.24015.bf

Genes

NOTCH3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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