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Article

NF-kappaB-dependent induction of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and Fas/FasL is crucial for efficient influenza virus propagation.

The Journal of biological chemistry - 23 Jul 2004

Wurzer Walter J, Ehrhardt Christina, Pleschka Stephan, Berberich-Siebelt Friederike, Wolff Thorsten, Walczak Henning, Planz Oliver, Ludwig Stephan

Abstract excerpt

Activation of the transcription factor NF-kappaB is a hallmark of infections by viral pathogens including influenza viruses. Because gene expression of many proinflammatory and antiviral cytokines is controlled by this factor, the concept emerged that NF-kappaB and its upstream regulator IkappaB kinase are essential components of the innate antiviral immune response to infectious pathogens. In contrast to this...

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Identifiers

PMID: 15143063
DOI: 10.1074/jbc.M403258200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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