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Article

Functions of yeast helicase Ssl2p that are essential for viability are also involved in protection from the toxicity of adriamycin.

Nucleic acids research - 1 Jan 2004

Furuchi Takemitsu, Takahashi Tsutomu, Tanaka Shogo, Nitta Katsushi, Naganuma Akira

Abstract excerpt

We have found that, in the yeast Saccharomyces cerevisiae, overexpression of the DNA helicase Ssl2p confers resistance to adriamycin. Ssl2p is involved, as a subunit of the basic transcription factor TFIIH, in the initiation of transcription and in nucleotide-excision repair (NER), and this helicase is essential for the survival of yeast cells. An examination of the relationship between the known functions of...

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Identifiers

PMID: 15141027
DOI: 10.1093/nar/gkh582
PMCID: PMC419470

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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