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Article

Pax7 Is Necessary and Sufficient for the Myogenic Specification of CD45+:Sca1+ Stem Cells from Injured Muscle

3 May 2004

Abstract excerpt

CD45(+):Sca1(+) adult stem cells isolated from uninjured muscle do not display any myogenic potential, whereas those isolated from regenerating muscle give rise to myoblasts expressing the paired-box transcription factor Pax7 and the bHLH factors Myf5 and MyoD. By contrast, CD45(+):Sca1(+) isolated from injured Pax7( -/-) muscle were incapable of forming myoblasts. Infection of CD45(+):Sca1(+) cells from...

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PMID: 15138500
DOI: 10.1371/journal.pbio.0020130

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