Article
The role of cytochrome P450 in cytotoxic bioactivation: future therapeutic directions.
Current cancer drug targets - 1 May 2004
Rooney P H, Telfer C, McFadyen M C E, Melvin W T, Murray G I
Abstract excerpt
The cytochrome P450s are an essential group of enzymes involved in metabolism of drugs, foreign chemicals, arachidonic acid, cholesterol, steroids and other important lipids. The cytochrome P450 enzyme system is responsible for much of the phase I metabolism of chemotherapeutic agents. At the simplest level the detoxification properties of the cytochrome P450s are used to help clear a cytotoxic before it results...
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