Article
Association of antioxidant enzyme gene polymorphisms and glutathione status with severe acute pancreatitis.
Gastroenterology - 1 May 2004
Rahman Sakhawat H, Ibrahim Khadija, Larvin Michael, Kingsnorth Andrew, McMahon Michael J
Abstract excerpt
BACKGROUND & AIMS: Genetic variations in antioxidant metabolism may explain varying biological responses to acute pancreatitis (AP). We studied the contribution of oxidative stress to the pathogenesis of severe pancreatitis by examining the prevalence of functional gene polymorphisms of antioxidant enzymes and evidence of heightened oxidative stress. METHODS: DNA from 320 patients with AP (90 severe) and 263...
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