Article
The effect of renin angiotensin system genetic variants in acute pancreatitis.
Annals of surgery - 1 Jan 2015
Skipworth James R A, Nijmeijer Rian M, van Santvoort Hjalmar C, Besselink Marc G H, Schulz Hans-Ulrich, Kivimaki Mika, Kumari Meena, Cooper Jackie A, Acharya Jay, Shankar Arjun, Malago Massimo, Humphries Steve E, Olde Damink Steven W M, Montgomery Hugh E
Abstract excerpt
OBJECTIVES: We sought association of genetic variants in the renin-angiotensin system (RAS) and vitamin D system with acute pancreatitis (AP) development and severity. BACKGROUND: The endocrine RAS is involved in circulatory homeostasis through the pressor action of angiotensin II at its AT1 receptor. However, local RAS regulate growth and inflammation in diverse cells and tissues, and their activity may be...
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