Article
Genetic polymorphisms of manganese-superoxide dismutase and glutathione-S-transferase in chronic alcoholic pancreatitis.
Mutagenesis - 1 Sept 2007
Osterreicher Christoph H, Schultheiss Jürgen, Wehler Markus, Homann Nils, Hellerbrand Claus, Künzli Beat, Friess Helmut, Seitz Helmut K, Stickel Felix
Abstract excerpt
Chronic alcohol consumption is a major risk factor for the development of chronic pancreatitis. However, chronic pancreatitis occurs only in a minority of heavy drinkers. This variability may be due to yet unidentified genetic factors. Several enzymes involved in the degradation of reactive oxidants and xenobiotics, such as glutathione-S-transferase P1 (GSTP1) and manganese-superoxide dismutase (MnSOD) reveal...
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