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Article

Role for glyoxalase I in Alzheimer's disease.

Proceedings of the National Academy of Sciences of the United States of America - 18 May 2004

Chen Feng, Wollmer M Axel, Hoerndli Frederic, Münch Gerald, Kuhla Björn, Rogaev Evgeny I, Tsolaki Magdalini, Papassotiropoulos Andreas, Götz Jürgen

Abstract excerpt

P301L mutant tau transgenic mice develop neurofibrillary tangles, a histopathologic hallmark of Alzheimer's disease and frontotemporal dementia (FTDP-17). To identify differentially expressed genes and to gain insight into pathogenic mechanisms, we performed a stringent analysis of the microarray dataset obtained with RNA from whole brains of P301L mutant mice and identified a single up-regulated gene, glyoxalase...

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Identifiers

PMID: 15128939
DOI: 10.1073/pnas.0402338101
PMCID: PMC419667

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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