Article
Role of the feline immunodeficiency virus L-domain in the presence or absence of Gag processing: involvement of ubiquitin and Nedd4-2s ligase in viral egress.
Journal of cellular physiology - 1 Jan 2009
Calistri Arianna, Del Vecchio Claudia, Salata Cristiano, Celestino Michele, Celegato Marta, Göttlinger Heinrich, Palù Giorgio, Parolin Cristina
Abstract excerpt
RNA-enveloped viruses bud from infected cells by exploiting the multivesicular body (MVB) pathway. In this context, ubiquitination of structural viral proteins and their direct interaction with cellular factors involved in the MVB biogenesis through short proline rich regions, named late domains (L-domains), are crucial mechanisms. Here we report that, in contrast with the human immunodeficiency virus (HIV), the...
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