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Article

Prognostic Significance of a Short Sequence Insertion in the MCL-1 Promoter in Chronic Lymphocytic Leukemia

4 May 2004

Abstract excerpt

BACKGROUND: Mcl-1 protein contributes to the longevity of chronic lymphocytic leukemia (CLL) B cells, and its higher expression has been associated with resistance to chemotherapy. We sought structural changes in the MCL-1 gene in CLL patients and associated these with clinical parameters of the disease. METHODS: The MCL-1 gene from peripheral blood lymphocytes from 58 CLL patients and 18 control subjects and...

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PMID: 15126604
DOI: 10.1093/jnci/djh122

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