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Article

Functional evidence for active site location of tetrameric thymidylate synthase X at the interphase of three monomers

27 Apr 2004

Abstract excerpt

Little is known about the catalytic mechanism of the recently discovered ThyX family of flavin-dependent thymidylate synthases that are required for thymidylate (deoxythymidine 5'-monophosphate) synthesis in a large number of microbial species. Using a combination of site-directed mutagenesis and biochemical measurements, we have identified several residues of the Helicobacter pylori ThyX protein with crucial...

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PMID: 15123820
DOI: 10.1073/pnas.0401365101

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