Evidence for unequal crossing over in the evolution of the neurofilament polypeptide H.

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Evidence for unequal crossing over in the evolution of the neurofilament polypeptide H.

The Journal of biological chemistry - 25 Aug 1992

Soppet D R, Beasley L L, Willard M B

Abstract excerpt

Two allelic forms of the rabbit neurofilament protein H, designated H1 and H2, differ by approximately 6% in their electrophoretic mobilities. We have used techniques of peptide and nucleic acid analysis to determine that this difference is located in the central portion of the COOH-terminal tail, a region of the H protein that can project from the filament, and may form cross-bridges. This region comprises...

Topics

Alleles
Amino Acid Sequence
Animals
Base Sequence
Biological Evolution
Blotting, Northern
Chromatography, High Pressure Liquid
Crossing Over, Genetic
DNA
Molecular Sequence Data
Neurofilament Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oligodeoxyribonucleotides

Peptide Fragments

RNA Probes

Rabbits

Repetitive Sequences, Nucleic Acid

Sequence Homology, Nucleic Acid

Spinal Cord

Source

Open in PubMed

Identifiers

PMID: 1512270

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1512270-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Evidence for unequal crossing over in the evolution of the neurofilament polypeptide H.PMID 1512270Read ↗

The evolutionary differentiation of two histone H2A.Z variants in chordates (H2A.Z-1 and H2A.Z-2) is mediated by a stepwise mutation process that affects three amino acid residues.Semantic proximity Read ↗

Structural diversity of the classical H-2 genes: K, D, and L.Semantic proximity Read ↗

Molecular evolution of myelin proteolipid protein.Semantic proximity Read ↗

Allelic variants of the canine heavy neurofilament (NFH) subunit and extensive phosphorylation in dogs with motor neuron disease.Semantic proximity Read ↗

The mouse factor H allotypes with multiple amino acid replacement, H.1 and H.2 show indistinguishable co-factor activity for factor I.Semantic proximity Read ↗

Evolution of the mouse H-2K region: a hot spot of mutation associated with genes transcribed in embryos and/or germ cells.Semantic proximity Read ↗

Molecular mapping of murine I region recombinants. III. Crossing over at two discrete sites within the beta 1-beta 2 intron of the E beta gene.Semantic proximity Read ↗

Molecular genetics of the S region of the murine H-2 major histocompatibility complex.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.