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Article

FLT3 mutation and response to intensive chemotherapy in young adult and elderly patients with normal karyotype.

Leukemia research - 1 Jun 2004

Beran Miloslav, Luthra Rajyalakshmi, Kantarjian Hagop, Estey Elihu

Abstract excerpt

The prognostic impact of FLT3 mutations on the outcome of patients with diploid AML, treated with intensive chemotherapy, was analyzed. In 176 patients, the frequency of single ITD was 30% (<61 years: 37%, >60 years: 23%), single D835 mutation 2.3%, and both 2.3%. There was no association between ITD and CR rate. ITD-positive patients <61 years had a higher frequency of resistant disease. ITD was adversely...

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Source

Identifiers

PMID: 15120929
DOI: 10.1016/j.leukres.2003.09.016

Genes

FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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