Article
Outcome of patients with FLT3-mutated acute myeloid leukemia in first relapse.
Leukemia research - 1 Jun 2010
Ravandi Farhad, Kantarjian Hagop, Faderl Stefan, Garcia-Manero Guillermo, O'Brien Susan, Koller Charles, Pierce Sherry, Brandt Mark, Kennedy Deborah, Cortes Jorge, Beran Miloslav
Abstract excerpt
Mutations of Fms-like tyrosine kinase-3 (FLT3) have been described in about 30% of patients with acute myeloid leukemia (AML) and are associated with a shorter disease-free and overall survival after initial therapy. We sought to examine whether the presence of these mutations in relapsed disease was also associated with a poor response to salvage chemotherapy by comparing the outcome of 34 patients with diploid...
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