Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The LIM-only proteins FHL2 and FHL3 interact with alpha- and beta-subunits of the muscle alpha7beta1 integrin receptor.

The Journal of biological chemistry - 2 Jul 2004

Samson Thomas, Smyth Neil, Janetzky Stefanie, Wendler Olaf, Müller Judith M, Schüle Roland, von der Mark Helga, von der Mark Klaus, Wixler Viktor

Abstract excerpt

FHL1, FHL2, and FHL3 are members of the four and one-half LIM domain protein subclass that are expressed in striated muscles. Here we show that FHL2 and FHL3 are novel alpha(7)beta(1) integrin-interacting proteins. They bind both the alpha- and the beta-subunit as well as different splice isoforms. The minimal binding sites for FHL2 and FHL3 on beta(1A)-chain overlap, whereas on alpha(7A) and alpha(7B) subunits...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dystroglycans
Share to Focal Adhesions

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Integrin alpha Chains

Share to Integrin beta1

Share to LIM Domain Proteins

Share to LIM-Homeodomain Proteins

Share to Muscles

Share to NIH 3T3 Cells

Source

Identifiers

PMID: 15117962
DOI: 10.1074/jbc.M312894200

Genes

FHL2
FHL3
FHL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The LIM-only proteins FHL2 and FHL3 interact with alpha- and beta-subunits of the muscle alpha7beta1 integrin receptor.PMID 15117962Read ↗

Genes, proteins and complexes: the multifaceted nature of FHL family proteins in diverse tissues.Semantic proximity Read ↗

Four and a half LIM protein 1 binds myosin-binding protein C and regulates myosin filament formation and sarcomere assembly.Semantic proximity Read ↗

Expression patterns of FHL/SLIM family members suggest important functional roles in skeletal muscle and cardiovascular systemSemantic proximity Read ↗

Four and a half LIM domains protein 1 can be as a double-edged sword in cancer progression.Semantic proximity Read ↗

Molecular cloning and characterization of FHL2, a novel LIM domain protein preferentially expressed in human heartSemantic proximity Read ↗

Characterization of tissue‐specific LIM domain protein (FHL1C) which is an alternatively spliced isoform of a human LIM‐only protein (FHL1)Semantic proximity Read ↗

FHL1 regulates myoblast differentiation and autophagy through its interaction with LC3Semantic proximity Read ↗

The multifunctional roles of the four-and-a-half-LIM only protein FHL2Semantic proximity Read ↗

Roles of focal adhesion proteins in skeleton and diseasesSemantic proximity Read ↗

Protein–protein interactions of the LIM-only protein FHL2 and functional implication of the interactions relevant in cardiovascular diseaseSemantic proximity Read ↗

A novel mechanism involving four-and-a-half LIM domain protein-1 and extracellular signal-regulated kinase-2 regulates titin phosphorylation and mechanics.Semantic proximity Read ↗

FHL2 (SLIM3) is not essential for cardiac development and function.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.