Article
CD14 promoter polymorphism (- 159C-->t) is not associated with myocardial infarction or coronary artery disease in patients with assumed high genetic risk.
The Thoracic and cardiovascular surgeon - 1 Oct 2009
Haberbosch W, Unkelbach K, Schuster D, Gardemann A, Tillmanns H, Hölschermann H
Abstract excerpt
OBJECTIVE: Inflammation plays a major role in the pathogenesis of coronary artery disease (CAD) and myocardial infarction (MI). CD14 is the receptor for bacterial lipopolysaccharide in monocytes and mediates the production of proinflammatory cytokines. The promoter of the CD14 gene has a polymorphic site in position - 159 (C-->T) and T-homozygotes have been shown to express higher amounts of CD14 by some...
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