Article
Coordinate downregulation of CaM kinase II and phospholamban accompanies contractile phenotype transition in the hyperthyroid rabbit soleus.
American journal of physiology. Cell physiology - 1 Sept 2004
Jiang M, Xu A, Jones D L, Narayanan N
Abstract excerpt
This study investigated the effects of l-thyroxine-induced hyperthyroidism on Ca(2+)/calmodulin (CaM)-dependent protein kinase (CaM kinase II)-mediated sarcoplasmic reticulum (SR) protein phosphorylation, SR Ca(2+) pump (Ca(2+)-ATPase) activity, and contraction duration in slow-twitch soleus muscle of the rabbit. Phosphorylation of Ca(2+)-ATPase and phospholamban (PLN) by endogenous CaM kinase II was found to be...
Topics
- Animals
- Blotting, Western
- Calcium
- Calcium-Binding Proteins
- Calcium-Calmodulin-Dependent Protein Kinase Type 2
- Calcium-Calmodulin-Dependent Protein Kinases
- Calcium-Transporting ATPases
- Down-Regulation
- Hyperthyroidism
- Male
- Muscle Contraction
- Muscle Fibers, Slow-Twitch