Article
Mutated form of the Newcastle disease virus hemagglutinin-neuraminidase interacts with the homologous fusion protein despite deficiencies in both receptor recognition and fusion promotion.
Journal of virology - 1 May 2004
Li Jianrong, Quinlan Edward, Mirza Anne, Iorio Ronald M
Abstract excerpt
The Newcastle disease virus (NDV) hemagglutinin-neuraminidase (HN) protein mediates attachment to cellular receptors. The fusion (F) protein promotes viral entry and spread. However, fusion is dependent on a virus-specific interaction between the two proteins that can be detected at the cell surface by a coimmunoprecipitation assay. A point mutation of I175E in the neuraminidase (NA) active site converts the HN...
Topics
- Amino Acid Sequence
- Animals
- Cricetinae
- HN Protein
- Membrane Fusion
- Molecular Sequence Data
- Mutation
- Newcastle disease virus
- Receptors, Virus
- Viral Fusion Proteins