Fusion mutants of Newcastle disease virus selected with monoclonal antibodies to the hemagglutinin-neuraminidase.

doi:10.1128/JVI.66.11.6626-6633.1992

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Article

Fusion mutants of Newcastle disease virus selected with monoclonal antibodies to the hemagglutinin-neuraminidase.

Journal of virology - 1 Nov 1992

Iorio R M, Glickman R L

Abstract excerpt

The Australia-Victoria (AV) isolate of Newcastle disease virus (NDV) induces fusion from within but not fusion from without. L1, a neuraminidase (NA)-deficient virus derived from AV, has the opposite fusion phenotype from the wild-type virus. It fails to induce the former mode of fusion, but has gained a limited ability to promote the latter. Monoclonal antibodies to antigenic site 23 on the...

Topics

Amino Acid Sequence
Antibodies, Monoclonal
Antibodies, Viral
Cell Fusion
Cells, Cultured
Genetic Variation
Hemagglutinins, Viral
Molecular Sequence Data
Mutagenesis
N-Acetylneuraminic Acid
Neuraminidase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Newcastle disease virus

Phenotype

Receptors, Virus

Sialic Acids

Structure-Activity Relationship

Viral Fusion Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 1404607
DOI: 10.1128/JVI.66.11.6626-6633.1992
PMCID: PMC240158

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1404607-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Fusion mutants of Newcastle disease virus selected with monoclonal antibodies to the hemagglutinin-neuraminidase.PMID 1404607Read ↗

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Two single amino acid substitutions in the intervening region of Newcastle disease virus HN protein attenuate viral replication and pathogenicity.Semantic proximity Read ↗

Loss of N-linked glycosylation from the hemagglutinin-neuraminidase protein alters virulence of Newcastle disease virus.Semantic proximity Read ↗

Biological Significance of Dual Mutations A494D and E495K of the Genotype III Newcastle Disease Virus Hemagglutinin-Neuraminidase In Vitro and In Vivo.Semantic proximity Read ↗

Antigenic and phylogenetic studies on a variant Newcastle disease virus using anti‐fusion protein monoclonal antibodies and partial sequencing of the fusion protein geneSemantic proximity Read ↗

Roles of the highly conserved amino acids in the second receptor binding site of the Newcastle disease virus HN proteinSemantic proximity Read ↗

Newcastle disease virus fusion and haemagglutinin-neuraminidase proteins contribute to its macrophage host rangeSemantic proximity Read ↗

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