Genome imprinting and cancer genetics.

Abstract excerpt

Parent-of-origin-dependent modification of the genome (genome imprinting) is thought to be involved in the formation of several types of human cancer. Simple modifications of Knudson's two-hit model give rise to two types of predictions with respect to the genetic behavior of such diseases. In the first, rare alleles of modifier genes will give rise to the retention of the same parent's tumor suppressor alleles...

Topics

• Genome, Human
• Humans
• Male
• Neoplasms
• Ovum
• Phenotype
• Spermatozoa