Article
Genome imprinting and carcinogenesis.
Biochimica et biophysica acta - 16 Apr 1991
Sapienza C
Abstract excerpt
The preferential retention of paternal tumor suppressor alleles in sporadic tumors and the failure to demonstrate genetic linkage between disease predisposition and tumor suppressor loci in familial cases indicates that genome imprinting may be involved in the genesis of some pediatric cancers. A genetic model that invokes the activity of modifier loci (imprinting genes) on alleles to be modified (imprinted...
Topics
- Alleles
- Genes, Dominant
- Genes, Tumor Suppressor
- Humans
- Neoplasms
- Phenotype