Article
Telomerase regulation at the telomere: a binary switch.
Cell - 30 Apr 2004
Loayza Diego, de Lange Titia
Abstract excerpt
Telomerase is known to preferentially elongate the shortest telomeres in a cell. Using an elegant yeast assay, Texeira et al. (2004 [this issue of Cell]) address what aspect of telomerase action is regulated by telomere length: the frequency or the extent of telomere elongation. They show that short telomeres are elongated more frequently than long telomeres, arguing that telomeres switch between two states, one...
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