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Article

Association between cytochrome P450 2D6 genotype and harm avoidance.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 15 May 2004

Roberts Rebecca L, Luty Suzanne E, Mulder Roger T, Joyce Peter R, Kennedy Martin A

Abstract excerpt

Genetic polymorphisms within the serotonergic and dopaminergic neurotransmitter systems may be associated with heightened harm avoidance and novelty seeking. It is also conceivable that polymorphisms in enzymes that mediate the metabolism of endogenous amines within the brain may influence these components of temperament. The CYP2D6 enzyme is expressed at low levels in the brain, and has been shown to mediate the...

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Identifiers

PMID: 15108188
DOI: 10.1002/ajmg.b.20163

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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