Article
Fundamental role of inferior olive connexin 36 in muscle coherence during tremor.
Proceedings of the National Academy of Sciences of the United States of America - 4 May 2004
Placantonakis Dimitris G, Bukovsky Anatoly A, Zeng Xiao-Hui, Kiem Hans-Peter, Welsh John P
Abstract excerpt
Inferior olive (IO) neurons are electrically coupled by cytosolic pores formed by the neuron-specific connexin 36 (Cx36). Electrical coupling in the IO figures prominently in current views about brain control of movement. However, a role for Cx36 in movement has been questioned and not definitively demonstrated. Previous reports have shown that embryonic deletion of the Cx36 gene resulted in almost complete loss...
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