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Article

ABCB1 1199G > A Polymorphism Impacts Transport Ability of P-gp-Mediated Antipsychotics.

DNA and cell biology - 1 Apr 2018

Wang Rong, Sun Xuan, Deng Yong-Shu, Qiu Xu-Wen

Abstract excerpt

The alterations in P-glycoprotein (P-gp)-mediated transport of antipsychotics due to the ABCB1 1199G>A polymorphism were assessed in the current study. The ABCB1wt and ABCB11199A recombinant cell models were constructed to study the sensitivity, intracellular accumulation, and transepithelial permeability of antipsychotic drugs. ABCB11199A recombinant cells had more sensitivity to olanzapine (2.2-fold, p < 0.01),...

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Identifiers

PMID: 29443543
DOI: 10.1089/dna.2017.4096

Genes

ABCB1

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